Background Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis
(JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti–…

Longâ•’term outcome and prognostic factors of juvenile dermatomyositis: A multinational,
multicenter study of 490 patients Page 1 Long-Term Outcome and Prognostic Factors of …

Thirteen children with difficult systemic onset juvenile rheumatoid arthritis were treated with
thalidomide. At 6 months, 11 of the 13 were able to reduce their use of prednisone (P < .002), …

Objectives To compare the demographic features, presenting manifestations, diagnostic
investigations, disease course, and drug therapies of children with juvenile dermatomyositis (…

Background To derive a list of opportunistic infections (OI) through the analysis of the juvenile
idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety …

Objective To assess childhood-onset systemic lupus erythematosus-related antiphospholipid
syndrome(cSLE-APS) in a large Brazilian population. Methods A retrospective …

Objective To evaluate the prevalence of genetic defects in clinically suspected autoinflammatory
syndromes (AIS) in a Brazilian multicenter study. Methods The study included 102 …

Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon
manifestations and associated diseases that may contribute to the delayed diagnosis. …

Objective To determine pregnancy outcome and fetal loss risk factors in patients with juvenile
systemic lupus erythematosus (JSLE). Methods A total of 315 female patients with JSLE …

To identify the underlying mechanism of amenorrhea in juvenile systemic lupus erythematosus
(JSLE) patients, thirty-five (11.7%) JSLE patients with current or previous amenorrhea …