TGF-β plays an important role in lung fibrosis, which is a major cause of suffering and death
seen in pulmonary disease. Smad7 has been recently identified as an antagonist of TGF-β …

… HIROSHI NAKAJIMA, ITSUO IWAMOTO, SANAE TOMOE, RYUTARO MATSUMURA,
HISAO TOMIOKA, KIYOSHI TAKATSU, and SHO YOSHIDA … NAKAJIMA, IWAMOTO …

Background: Galectin-β is a p-galactoside-binding protein which is implicated in diverse
physiological and pathological processes including human liver cirrhosis and a mouse lung …

Regulatory T cells (T reg cells) can activate multiple suppressive mechanisms in vitro after
activation via the T cell antigen receptor, resulting in antigen-independent suppression. …

Importance The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated
vasculitis is the combination of high-dose glucocorticoids and …

Objective The aim of this prospective multicenter study was to identify biomarkers that can
be used to predict therapeutic responses to tocilizumab in patients with rheumatoid arthritis (…

Objective. Patients with eosinophilic granulomatosis with polyangiitis (EGPA) frequently
experience relapses, which lead to cumulative organ damage. In this retrospective …

Mice homozygous for an autosomal recessive mutation aly (alymphoplasia) lack both lymph
nodes and Peyer’s patches, and show defects in both humoral and cellular immunity. …

Introduction Patients with rheumatoid arthritis (RA) treated with abatacept (ABT) are at
increased risk for vaccine-preventable infections. The aim of the present study is to evaluate the …

Objective. Although several miRNAs have been shown to regulate autoimmune pathogenesis
by affecting lymphocyte function, the roles of miRNAs in the pathogenesis of SSc remain …