Human organic anion transporter 2 (hOat2 [SLC22A7]) is highly expressed in the human liver.
Although localization, gene expression, substrate specificity and transport mechanisms of …

We identified the Drosophila trio gene, which encodes a Dbl family protein carrying two Dbl
homology (DH) domains, each of which potentially activates Rho family GTPases. Trio was …

Objective. To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-modifying
antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients …

… Dr Nakajima and Dr Sakai contributed equally to 35% of this work in planning, data analysis,
interpretation of results, and writing this manuscript. Dr Harigai contributed to 20% of this …

Objective To investigate associations between continuous treatments with tumor necrosis
factor (TNF) antagonists and risk for developing serious infections (SIs) over 3 years in …

Introduction The objective of this study was to directly compare the safety of tocilizumab (TCZ)
and TNF inhibitors (TNFIs) in rheumatoid arthritis (RA) patients in clinical practice. …

Objectives: To investigate and compare the risk for malignancy in rheumatoid arthritis (RA)
patients treated with biologics in Japan to the general population. Methods: Data for 14,440 …

Background Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the
prophylaxis of Pneumocystis pneumonia (PJP) in immunosuppressed patients with systemic …

Objectives The association of anti-tumor necrosis factor therapy with opportunistic infections
in rheumatoid arthritis (RA) patients has been reported. The goal of this study was to clarify …

Objectives To investigate the risk factors and clinical characteristics of lymphoproliferative
disorder (LPD) in Japanese patients with rheumatoid arthritis (RA). Methods We enrolled …