OBJECTIVE: To determine the prevalence of severe infections in patients with rheumatoid
arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand. METHODS: A case-…

Introduction and Objectives There is increasing evidence to suggest that therapeutic doses
of metformin are unlikely to cause lactic acidosis. The aims of this research were (1) to …

A case series of hepatotoxicity associated with an extract of Artemisia annua L. was identified
through the New Zealand spontaneous adverse drug reaction reporting system. A. annua …

It is well established that variations in genes can alter the pharmacokinetic and
pharmacodynamic profile of a drug and immunological responses to it. Early advances in …

Study Objectives: To assess adverse drug reaction reports of “abnormal sleep related events”
associated with varenicline, a partial agonist to the α4β2 subtype of nicotinic acetylcholine …

We describe 7 cases of synovitis or arthritis occurring after commencement of alendronate
for treatment of osteoporosis. These were cases from our practice or notified to the New …

Background Diclofenac, a nonsteroidal anti-inflammatory drug, is not a documented cause
of rhabdomyolysis in the Summaries of Product Characteristics held by major regulators. …

Like the patient described by Dr RW Gange and Professor E Wilson Jones (1 April, p 816),
our patient had been taking labetalol 400 mg twice daily for three months when his …

Alcorn et al.[1] have provided a welcome benefit-risk assessment of leflunomide use in the
treatment of rheumatoid arthritis based on a review of the literature to 2008. The adverse …

Three publications, including two recently in Diabetes Care, have indicated that a combination
of rosiglitazone and fibrates may lower serum HDL cholesterol in some patients (1-3). It is …