Objective Although oral bisphosphonates are effective treatments for postmenopausal
women with osteoporosis, oral dosing may be unsuitable for some patients. An efficacious …

Connexin(Cx)43 is the major gap junction protein present in osteoblasts. We have shown
that overexpression of Cx45 in osteoblasts expressing endogenous Cx43 leads to decreased …

Background Antiresorptive agents for the treatment of osteoporosis suppress bone
remodeling and reestablish bone turnover at a lower rate to reduce bone loss. Recombinant …

Background: A previous study reported by this group found that patients in periodontal
maintenance programs taking vitamin D and calcium supplementation had a trend for better …

Skeletal development (bone modeling) and its maintenance in post-natal life in response to
local and systemic stimuli (bone remodeling) require coordinated activity among osteoblasts …

Background: A low dietary intake of vitamin D and calcium hastens bone loss and osteoporosis.
Because vitamin D metabolites may also alter the inflammatory response and have …

Mutations of critical components of the Wnt pathway profoundly affect skeletal development
and maintenance, probably via modulation of β‐catenin signaling. We tested the hypothesis …

Bone-forming cells are organized in a multicellular network interconnected by gap junctions.
In these cells, gap junctions are formed by connexin43 (Cx43) and connexin45 (Cx45). …

Estrogen treatment improves calcium malabsorption induced by surgical or natural menopause,
but the mechanisms involved are still under debate, with both increased production of 1,…

To define the potential role of subclinical vitamin D deficiency in postmenopausal bone loss,
we analyzed the levels of circulating 25-hydroxyvitamin D (25OHD) in 539 midwestern …