User profiles for Richard Wu
 | Wu RichardUniversity of Pittsburgh Medical Center Verified email at upmc.edu Cited by 1907 |
[HTML][HTML] Neoadjuvant–adjuvant or adjuvant-only pembrolizumab in advanced melanoma
…, JA Sosman, KL Kendra, RC Wu… - … England Journal of …, 2023 - Mass Medical Soc
Background Whether pembrolizumab given both before surgery (neoadjuvant therapy) and
after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant …
after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant …
[HTML][HTML] Effect of a monoclonal antibody to PCSK9 on LDL cholesterol
…, E Lisbon, M Gutierrez, C Webb, R Wu… - … England Journal of …, 2012 - Mass Medical Soc
Background Proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases,
binds to low-density lipoprotein (LDL) receptors, leading to their accelerated degradation and …
binds to low-density lipoprotein (LDL) receptors, leading to their accelerated degradation and …
Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial …
…, J Bergeron, D Gaudet, R Weiss, R Dufour, R Wu… - The Lancet, 2012 - thelancet.com
Background Inhibition of proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9)
resulted in large reductions of low-density lipoprotein cholesterol (LDL-C) in phase 1 …
resulted in large reductions of low-density lipoprotein cholesterol (LDL-C) in phase 1 …
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled …
…, JC Szepietowski, H Sofen, M Kawashima, R Wu… - The Lancet, 2016 - thelancet.com
Background Data from early-stage studies suggested that interleukin (IL)-4 and IL-13 are
requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with …
requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with …
Pulmonary vein anatomy in patients undergoing catheter ablation of atrial fibrillation: lessons learned by use of magnetic resonance imaging
R Kato, L Lickfett, G Meininger, T Dickfeld, R Wu… - Circulation, 2003 - Am Heart Assoc
Background— This study sought to define the technique and results of magnetic resonance
imaging (MRI) of pulmonary vein (PV) anatomy before and after catheter ablation of atrial …
imaging (MRI) of pulmonary vein (PV) anatomy before and after catheter ablation of atrial …
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
Purpose: Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL)
is a promising treatment for metastatic melanoma unresponsive to conventional therapies. …
is a promising treatment for metastatic melanoma unresponsive to conventional therapies. …
[HTML][HTML] Patient burden of moderate to severe atopic dermatitis (AD): insights from a phase 2b clinical trial of dupilumab in adults
EL Simpson, T Bieber, L Eckert, R Wu… - Journal of the American …, 2016 - Elsevier
Background The adult burden of atopic dermatitis (AD) is poorly characterized. Objective
We sought to characterize AD burden in adults with moderate to severe disease from the …
We sought to characterize AD burden in adults with moderate to severe disease from the …
Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook
Immunotherapy using autologous T cells has emerged to be a powerful treatment option for
patients with metastatic melanoma. These include the adoptive transfer of autologous tumor-…
patients with metastatic melanoma. These include the adoptive transfer of autologous tumor-…
Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions
…, WS Yamanashi, J Edwards, J Zhou, R Wu… - Heart rhythm, 2006 - Elsevier
BACKGROUND: The mechanism(s) by which pulmonary veins (PVs) become ectopically
active and subsequently initiate and sustain atrial fibrillation (AF) remains poorly understood. …
active and subsequently initiate and sustain atrial fibrillation (AF) remains poorly understood. …
Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor
Immune checkpoint therapy has revolutionized cancer treatment by blocking inhibitory pathways
in T cells that limits the an effective anti-tumor immune response. Therapeutics targeting …
in T cells that limits the an effective anti-tumor immune response. Therapeutics targeting …