To complement the hard variables generally used in the assessment of different treatments
for cancer and other chronic diseases we developed a ‘hardened’, succinct quantitative …

Meta-analysis was used to examine 108 intervention comparisons in 39 controlled smoking
cessation trials. Type of intervention (face-to-face advice being better than all others), type of …

Most elderly persons with dementia are cared for at home, usually by the spouse or an adult
child. The objective of the present study was to determine whether there is an excess of …

This paper examines a process for evaluating clinical effectiveness and developing
recommendations in which systematic methods are used to review evidence from published clinical …

Objective: To determine the effectiveness of aspirin in preventing ischemic events in patients
with asymptomatic carotid stenosis. Design: Double-blind, placebo-controlled trial. Setting: …

Thirty years ago an American congressman said,“Technical information needed by policy
makers is frequently not available, or not in the right form.… Technology assessment is a form …

Objective: To estimate the change in depression and physical symptoms during a 1-year
period in a group of caregivers for elderly persons with dementia and in a group of comparison …

OBJECTIVE: We evaluated different methods for quantifying patient-physician discordance
and identified factors associated with discordance in the assessment of lupus disease activity…

Canada's health system is a unique combination of public financing and private provision.
With the significant government role in financing health services, health technology …

Objectives: The complexity of health technology assessment (HTA) has increased, in part
because of its evolution through three distinct phases: the machine, the clinical outcomes, and …