Antigen-specific suppression of a previously primed immune response is a major challenge
for immunotherapy of autoimmune disease. RelB activation is required for myeloid DC …

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1
locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-…

Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …

Objective To investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying
antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA). …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the
joints. The prevalence of RA varies globally, with generally a higher prevalence in …

In animals, immunomodulatory dendritic cells (DCs) exposed to autoantigen can suppress
experimental arthritis in an antigen-specific manner. In rheumatoid arthritis (RA), disease-…

During thymopoiesis, a unique program of gene expression promotes the development of
CD4 regulatory T (T reg) cells. Although Foxp3 maintains a pattern of gene expression …

Objective. Interleukin‐10 (IL‐10) has been shown to exert both antiinflammatory and
immunostimulatory effects in vivo and in vitro. We therefore sought to examine the role of this …

Objective Ankylosing spondylitis (AS) is a common inflammatory arthritis affecting primarily
the axial skeleton. IL23R is genetically associated with AS. This study was undertaken to …

Introduction The aim of this study was to characterize interleukin 17 (IL-17) and interleukin
22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial …