The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate
polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we …

Objective Systemic juvenile idiopathic arthritis (JIA) is associated with high levels of interleukin‐6
(IL‐6) in the serum and synovial fluid, and impairment of natural killer (NK) cell function …

Epithelial-to-mesenchymal transition (EMT) occurs in fibrotic diseases affecting the kidney,
liver and lung, and in the peritoneum of patients undergoing peritoneal dialysis. EMT in the …

Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this
treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes …

Nerve growth factor (NGF) levels are highly increased in inflamed tissues, but their role is
unclear. We show that NGF is part of a regulatory loop in monocytes: inflammatory stimuli, …

Objective To investigate whether prolonged exposure to interleukin‐6 (IL‐6) affects the
inflammatory response induced by Toll‐like receptor (TLR) ligands. Methods IL‐6–transgenic …

Background The pathogenesis of macrophage activation syndrome (MAS) is not clearly
understood: a large body of evidence supports the involvement of mechanisms similar to those …

Repertaxin is a new non-competitive allosteric blocker of interleukin-8 (CXCL8/IL-8) receptors
(CXCR1/R2), which by locking CXCR1/R2 in an inactive conformation prevents receptor …

Epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells is a pathological
process that occurs during peritoneal dialysis. EMT leads to peritoneal fibrosis, ultrafiltration …

Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …