Introduction In the present study, we analysed in detail nuclear autoantibodies and their
associations in systemic sclerosis (SSc) patients included in the German Network for Systemic …

The detection of autoantibodies is an important element in the diagnosis and monitoring of
disease progression in patients with autoimmune diseases. In laboratory diagnostic tests for …

Patients selected for the presence of sclerodermarelated antibodies (anti‐DNA‐topoisomerase
I [antitopo I; n = 43], anticentromere antibody [ACA; n = 63], or anti‐Pm‐Scl [n = 12]) were …

The autoantigenic polymyositis/scleroderma (PM/Scl) complex was recently shown to be the
human homologue of the yeast exosome, which is an RNA-processing complex. Our aim …

Objective. To characterize the clinical and immunogenetic features of patients with Mi‐2
autoantibodies. Methods. Eighteen adult white patients with Mi‐2 antibodies were clinically …

Different nephelometric assay systems for quantitation of C-reactive protein (CRP) were
compared with radial immunodiffusion (RID) and tested for their susceptibility to interference by …

Autoimmune diseases arise from a host's immune response against self-antigens. The
triggering events ultimately resulting in such a break of tolerance are largely unknown. It is also …

The major targets recognized by anti-centromere autoantibodies are the three centromere-associated
proteins (CENPs) A, B, and C, with apparent molecular masses of 19, 80, and 140 …

Antibodies directed against an epitope motif on CENP‐A have been shown to cross‐react
with mimotopes on other autoantigens and on Epstein‐Barr nuclear antigen 1 (EBNA‐1), …

Diagnosis of rheumatoid arthritis (RA) is mainly based on clinical criteria of symmetric
polyarthritis of the hands and feet, with morning stiffness lasting usually more than 1h. …