Objective. The ability of antiinflammatory strategies to alter cardiovascular risk has not been
rigorously examined. Colchicine is an antiinflammatory agent that affects macrophages, …

BACKGROUND: Patients with gout have comorbidities, but the impact of these comorbidities
on treatment has not been studied. METHODS: A total of 575 patients with gout were …

Objectives Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added
to allopurinol in patients with serum uric acid (sUA) above target in a 12-month, randomised…

Urate is the end-product of the purine metabolism in humans. The dominant source of urate
is endogenous purines and the remainder comes through diet. Approximately two thirds of …

Objective The language currently used to describe gout lacks standardization. The aim of
this project was to develop a consensus statement on the labels and definitions used to …

Objective There is a lack of standardisation in the terminology used to describe gout. The
aim of this project was to develop a consensus statement describing the recommended …

Gout is a chronic disease in which excessively high levels of serum urate (hyperuricemia)
result in tissue depositions of sodium urate crystals and intermittent inflammatory attacks. …

Objective To evaluate the efficacy and safety of anakinra compared to triamcinolone in the
treatment of gout flares. Methods Patients for whom nonsteroidal antiinflammatory drugs and …

Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular
disease. However, studies have frequently failed to distinguish whether these entities have an …

Introduction Pegloticase is a recombinant PEGylated uricase that converts relatively insoluble
urate to highly water-soluble allantoin, which is readily excreted by the kidneys. It is the …