Endothelium structure and function in kidney health and disease

…, J Bellien, S Burtey, M Frimat, PA Jarrot… - Nature Reviews …, 2019 - nature.com
The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

…, K Mazodier, V Pestre, PA Jarrot… - Proceedings of the …, 2020 - National Acad Sciences
Around the tenth day after diagnosis, ∼20% of patients with coronavirus disease 2019 (COVID-19)−associated
pneumonia evolve toward severe oxygen dependence (stage 2b) and …

Natural history of COVID-19 and therapeutic options

P Gautret, M Million, PA Jarrot… - Expert review of …, 2020 - Taylor & Francis
Introduction: COVID-19 presents benign forms in young patients who frequently present with
anosmia. Infants are rarely infected, while severe forms occur in patients over 65 years of …

Pathogenesis of ANCA-associated vasculitis: an update

PA Jarrot, G Kaplanski - Autoimmunity reviews, 2016 - Elsevier
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes a group
of rare diseases characterized by necrotizing inflammation of small blood vessels and the …

NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient

S Van Bruggen, PA Jarrot, E Thomas… - Proceedings of the …, 2023 - National Acad Sciences
Neutrophil recruitment to sites of infection and inflammation is an essential process in the
early innate immune response. Upon activation, a subset of neutrophils rapidly assembles the …

Neutrophil extracellular traps are associated with the pathogenesis of diffuse alveolar hemorrhage in murine lupus

PA Jarrot, E Tellier, L Plantureux, L Crescence… - Journal of …, 2019 - Elsevier
Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus
erythematosus (SLE) and systemic vasculitis. Although initially described to have antibacterial …

[HTML][HTML] Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome in patients with biopsy-proven …

PA Jarrot, L Chiche, B Hervier, L Daniel, V Vuiblet… - Medicine, 2016 - journals.lww.com
The aim of the study was to report the clinical, biological, and pathological characteristics of
patients with glomerulonephritis (GN) secondary to systemic lupus erythematosus (SLE)/…

[HTML][HTML] Clinical characteristics and outcomes of patients with haematologic malignancies and COVID-19 suggest that prolonged SARS-CoV-2 carriage is an …

R Arcani, J Colle, R Cauchois, M Koubi, PA Jarrot… - Annals of …, 2021 - Springer
Specificities of COVID-19 disease course in patients with haematologic malignancies are
still poorly studied. So, we aimed to compare patients with haematologic malignancies to …

[HTML][HTML] Eosinopenia as predictor of poor outcome in hospitalized COVID-19 adult patients from waves 1 and 2 of 2020 pandemic

…, N Cassir, N Potere, I Polidoro, R Jean, PA Jarrot… - Microorganisms, 2022 - mdpi.com
During SARS-CoV-2 infection, eosinopenia may reflect a hyperactive immune response. In
this study of hospitalized COVID-19 patients, we aimed to better understand the prognostic …

[HTML][HTML] Anti-TNF-alpha therapy and systemic vasculitis

PA Jarrot, G Kaplanski - Mediators of Inflammation, 2014 - hindawi.com
TNF-α is a pleiotropic cytokine, which plays a major role in the pathogenesis of numerous
autoimmune and/or inflammatory systemic diseases. Systemic vasculitis constitutes a group of …