Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community

…, PJW Venables, MJ Wattiaux, P Youinou - … : Official Journal of …, 1993 - Wiley Online Library
Objective. Different sets of diagnostic criteria have been proposed for Sjögren's syndrome (SS),
but none have been validated with a large series of patients or in a multicenter study. We …

The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis

GJ Tobón, P Youinou, A Saraux - Autoimmunity reviews, 2010 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by a distinctive
pattern of bone and joint destruction. RA patients have an increased risk of death. The …

BAFF overexpression is associated with autoantibody production in autoimmune diseases

…, A Saraux, C Jamin, P Youinou - Annals of the New …, 2005 - Wiley Online Library
The B‐cell activity factor (BAFF) acts as a positive regulator of B‐cell function. To gain further
insight into the understanding of B‐cell hyperactivity in autoimmune diseases, the serum …

Improvement of Sjögren's syndrome after two infusions of rituximab (anti‐CD20)

…, IQ Roué, B Cochener, P Youinou… - Arthritis care & …, 2007 - Wiley Online Library
Objective. There is evidence to support a dominant role for B cells in the pathophysiology of
primary Sjögren's syndrome

Epigenetics and autoimmunity

WH Brooks, C Le Dantec, JO Pers, P Youinou… - Journal of …, 2010 - Elsevier
Advances in genetics, such as sequencing of the human genome, have contributed to
identification of susceptible genetic patterns in autoimmune diseases (AID). However, genetics is …

Contribution of salivary gland ultrasonography to the diagnosis of Sjögren's syndrome: toward new diagnostic criteria?

…, S Boisramé‐Gastrin, E Nowak, P Youinou… - Arthritis & …, 2013 - Wiley Online Library
Objective To determine the accuracy of salivary gland ultrasonography (SGUS) for
diagnosing primary Sjögren's syndrome (SS) and to suggest modifications of the American–European …

Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndrome

…, M Dueymes, A Saraux, P Youinou… - Arthritis & …, 2007 - Wiley Online Library
Objective. To identify the cells that produce BAFF in the salivary glands of patients with
primary Sjögren’s syndrome (SS), and to analyze BAFF receptor expression by local T and B …

Ability of the American College of Rheumatology 1987 criteria to predict rheumatoid arthritis in patients with early arthritis and classification of these patients two years …

…, E Botton, JY Mary, P Le Goff, P Youinou - Arthritis & …, 2001 - Wiley Online Library
Objective To determine how well the American College of Rheumatology (ACR; formerly,
the American Rheumatism Association) 1987 classification criteria for rheumatoid arthritis (RA), …

Anti–TNF‐α immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis

…, A Saraux, R Pierre, P Youinou - Journal of …, 2008 - Wiley Online Library
Background: Because periodontitis presents many similarities with rheumatoid arthritis (RA)
with regard to tumor necrosis factor‐alpha (TNF‐α)‐induced bone resorption, the benefits of …

The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis.

…, JC Piette, Y Shoenfeld, PY Youinou - The Journal of …, 1998 - Am Soc Clin Investig
Youinou, manuscript submitted for publication). Studies are in progress to identify the cell
surface epitope(s) that apoptosis-inducing AECA recognize. Further analysis of human …