Stored blood samples from 164 intravenous drug abusers who attended a Scottish general
practice were tested for HTLV-III/LAV (human T cell lymphotropic virus type III/…

Low-voltage-activated (LVA) Ca 2+ channels are widely distributed throughout the CNS and
are important determinants of neuronal excitability, initiating dendritic and somatic Ca 2+ …

Little is known about the mechanisms underlying the enhancement of long‐term potentiation
(LTP) by nicotine. In the present study, the mechanisms of nicotinic enhancement of LTP …

Lipid‐based nanoparticles have recently shown great promise, establishing themselves as
the gold standard in delivering novel RNA therapeutics. However, research on the effects of …

We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs)
enhanced long‐term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR…

Ang II receptor activation increases cytosolic Ca 2+ levels to enhance the synthesis and
secretion of aldosterone, a recently identified early pathogenic stimulus that adversely …

Glycogen phosphorylase (GP) is the rate-determining enzyme in the glycogenolysis pathway.
Glioblastoma (GBM) is amongst the most aggressive cancers of the central nervous system…

For the first time, the in silico design, screening, and in vitro validation of potent GSK-3β type-II
inhibitors are presented. In the absence of crystallographic evidence for a DFG-out GSK-…

In clinical medicine, a balance needs to be struck between reductionism (the view that a system
can be fully understood in terms of its isolated parts) and holistic complexity appreciation …

Nicotine has been postulated to be a possible neuroprotective agent in Alzheimer's Disease
(AD). In the present studies, the effect of beta-amyloid (Aβ) was investigated on the nicotine …