Ku, also known as nuclear Factor IV, is an abundant nuclear DNA-binding protein which
requires free DNA ends for the initial interaction with double-stranded DNA (dsDNA) and can …

The normal functioning immune system is programmed to attack foreign pathogens and
other foreign proteins while maintaining tolerance to self-proteins. The mechanisms by which …

Objective Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and
arthritis, for which interleukin‐1 (IL‐1) and IL‐6 inhibitors appear to be effective treatments. …

… met the definite criteria for JDM as defined by modified Bohan and Peter criteria. Bohan and
Peter criteria were modified by the CARRA Legacy Registry project investigators to include …

Juvenile fibromyalgia (JFM), a chronic disorder of widespread musculoskeletal pain in
combination with autonomic, sensory, and cognitive dysfunction, is responsible for considerable …

OBJECTIVE: To determine serum levels of adhesion molecules ICAM-1, ICAM-3, VCAM-1, L-selectin,
and E-selectin in children with a variety of pediatric rheumatic diseases and …

In a number of different strains of inbred mice, immunization with a hapten coupled to a protein
carrier results in production of homogeneous serum antibodies. At the genetic level this …

Thrombotic thrombocytopenic purpura (TTP) rarely occurs with systemic vasculitis. A 17-year-old
girl presented with non-bloody diarrhea, menorrhagia, and syncope. She had severe …

Objective Few data are available regarding the rates of serious adverse events (SAEs) and
important medical events (IMEs) outside of product‐based registries and clinical trials for …

Binding properties ofa murine (NZB x NZWF 1) monoclonal anti-ssDNA autoantibody (BV04-01)
was compared with another anti-ssDNA autoantibody mV16-19). Both monoclonal …