Chitosan scaffolds appear to be suitable for a variety of tissue engineering applications. This
study addressed the biocompatibility of chitosan in a mouse implantation model. Porous …

A model of arthritis was established by the injection of type II collagen into mice. Only mice
bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further …

A recombinant human TNF receptor Fc fusion protein (rhuTNFR:Fc) was assessed for
antiarthritic activity using murine type II collagen-induced arthritis in mice. DBA/1 mice were …

Natural bone growth greatly depends on the precedent vascular network that supplies
oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-…

Although total joint replacement surgery is one of the most successful clinical procedures
performed today, bone loss around knee and hip implants (osteolysis), resulting in aseptic …

Composite analogue bone models provide consistent geometric and structural properties
that represent a valuable asset in a range of biomechanical analyses and testing procedures. …

An in vivo model of the inflammatory response to orthopaedic biomaterials was used to
examine cellular and cytokine responses to polymer particles of ultra high molecular weight …

Rheumatoid arthritis (RA) is the most common, crippling human autoimmune disease.
Using Western blotting and tandem mass spectroscopy, we have identified the endoplasmic …

Periprosthetic osteolysis is the most common longterm complication of a total joint arthroplasty,
often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger …

The wear of orthopaedic prostheses results in the release of a markedly heterogeneous
assortment of particulate debris, with respect to both size and shape. Although particle size has …