Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation
P Leclerc, H Idborg, L Spahiu, C Larsson… - Prostaglandins & other …, 2013 - Elsevier
Microsomal prostaglandin E synthase-1 (mPGES-1) inhibition has been suggested as an
alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. We …
alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. We …
Anti-inflammatory cytokine profile in early human tendon repair
PW Ackermann, E Domeij-Arverud, P Leclerc… - Knee surgery, sports …, 2013 - Springer
Purpose The aim of this study was to assess inflammation and the presence and relative
levels of cytokines, which may be involved in regulating early human Achilles tendon healing. …
levels of cytokines, which may be involved in regulating early human Achilles tendon healing. …
The Toll‐like receptor 7/8‐ligand resiquimod (R‐848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet‐activating factor biosynthesis
…, S Picard, M Borgeat, P Leclerc… - The FASEB …, 2007 - Wiley Online Library
Toll‐like receptors (TLR) recognize pathogen‐associated molecular patterns and play
important roles in the innate immune system. While single‐stranded viral RNA is the natural …
important roles in the innate immune system. While single‐stranded viral RNA is the natural …
Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal
JS Cadieux, P Leclerc, M St-Onge… - Journal of cell …, 2005 - journals.biologists.com
Neutrophils, which are often the first to migrate at inflamed sites, can generate leukotriene B
4 from the 5-lipoxygenase pathway and prostaglandin E 2 through the inducible …
4 from the 5-lipoxygenase pathway and prostaglandin E 2 through the inducible …
Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice
H Idborg, P Olsson, P Leclerc, J Raouf… - Prostaglandins & other …, 2013 - Elsevier
mPGES-1 is considered an alternative target for anti-inflammatory treatment with improved
selectivity and safety compared to NSAIDs. mPGES-1 depletion not only suppresses …
selectivity and safety compared to NSAIDs. mPGES-1 depletion not only suppresses …
Serotonin 5‐HT2A and 5‐HT5A receptors are expressed by different motoneuron populations in rat Onuf's nucleus
…, XQ Sun, MJ Brisorgueil, P Leclerc… - Journal of …, 2007 - Wiley Online Library
Motoneurons of Onuf's nucleus innervate the pelvic striated muscles, which play a crucial role
in erection, ejaculation, and urinary continence. Serotonergic descending projections from …
in erection, ejaculation, and urinary continence. Serotonergic descending projections from …
Characterization of a new mPGES-1 inhibitor in rat models of inflammation
P Leclerc, SC Pawelzik, H Idborg, L Spahiu… - Prostaglandins & other …, 2013 - Elsevier
Microsomal prostaglandin E synthase (mPGES)-1 inhibition has been proposed as an
alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. This …
alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. This …
Work-Related Issues and Physical and Psychological Burden in Canadian Patients With Axial Spondyloarthritis: Results From the International Map of Axial …
…, G Major, MG Mallinson, S Rohekar, P Leclerc… - The Journal of …, 2023 - jrheum.org
Objective To identify factors associated with work-related issues in Canadian patients with
axial spondyloarthritis. Methods Data from 542 Canadian patients who participated in the …
axial spondyloarthritis. Methods Data from 542 Canadian patients who participated in the …
TNF production in macrophages is genetically determined and regulates inflammatory disease in rats
Dysregulation of TNF is an important pathophysiological phenotype for many diseases.
Recently, certain genetically regulated loci have been identified to regulate several inflammatory …
Recently, certain genetically regulated loci have been identified to regulate several inflammatory …
[HTML][HTML] Expression of Prostaglandin E2 Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients
MJH de Hair, P Leclerc, EC Newsum, KI Maijer… - PLoS …, 2015 - journals.plos.org
Objective Arthralgia may precede the development of synovial inflammation in autoantibody-positive
individuals at risk of developing rheumatoid arthritis (RA). A major pathway …
individuals at risk of developing rheumatoid arthritis (RA). A major pathway …