Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (–)-cis-1-methyl-7-[[4-(2, 6-dichlorophenyl) …
PF Zaratin, G Petrone, M Sbacchi, M Garnier… - … of Pharmacology and …, 2004 - ASPET
(–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol
(SB-612111) is a novel human opiate receptor-like orphan receptor (ORL-1…
(SB-612111) is a novel human opiate receptor-like orphan receptor (ORL-1…
Evidence for a selective role of the δ-opioid agonist [8R-(4bS*, 8aα, 8aβ, 12bβ)] 7, 10-Dimethyl-1-methoxy-11-(2-methylpropyl) oxycarbonyl 5, 6, 7, 8, 12, 12b …
…, S Bingham, G Ficalora, M Garnier, PF Zaratin… - … of Pharmacology and …, 2003 - ASPET
The specific involvement of the δ-opioid receptor in the control of nociception was explored
by investigating the pharmacological activity in vivo of a selective, orally active, and centrally …
by investigating the pharmacological activity in vivo of a selective, orally active, and centrally …
Constitutive expression of angiopoietin-1 and-2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.
BB Scott, PF Zaratin, A Colombo, MJ Hansbury… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: Angiopoietin- I (Ang-1) and Ang-2 are ligands for the receptor tyrosine kinase,
Tie-2. Ang-1, a Tie-2 agonist, may have a vascular stabilizing role in angiogenesis, while Ang…
Tie-2. Ang-1, a Tie-2 agonist, may have a vascular stabilizing role in angiogenesis, while Ang…
Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine
M Garnier, PF Zaratin, G Ficalora, M Valente… - … of Pharmacology and …, 2003 - ASPET
We hypothesized that the up-regulated expression of one or more members of the regulator
of G protein signaling (RGS) family can cause an attenuation of signaling via Gi/Go-coupled …
of G protein signaling (RGS) family can cause an attenuation of signaling via Gi/Go-coupled …
Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers
…, G Comi, G Martino, PF Zaratin - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background:Autoimmune activation and deregulated apoptosis of T lymphocytes are involved
in multiple sclerosis (MS). c-Jun N-terminal kinase (JNK) plays a role in T-cell survival and …
in multiple sclerosis (MS). c-Jun N-terminal kinase (JNK) plays a role in T-cell survival and …
Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies
PF Zaratin, A Quattrini, SC Previtali, G Comi… - Molecular and Cellular …, 2005 - Elsevier
The human 7-transmembrane receptor GPR7 has sequence similarity to opioid and
somatostatin receptors, and can be activated by the recently discovered neuropeptides NPB and …
somatostatin receptors, and can be activated by the recently discovered neuropeptides NPB and …
Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin …
…, A Kazantzis, A Kapurniotu, PF Zaratin… - Journal of medicinal …, 2002 - ACS Publications
We have recently reported the potent hypocalcemic effects of side-chain lactam-bridged
analogues of human calcitonin (hCT) (Kapurniotu, A.; et al. Eur. J. Biochem. 1999, 265, 606−618…
analogues of human calcitonin (hCT) (Kapurniotu, A.; et al. Eur. J. Biochem. 1999, 265, 606−618…
[HTML][HTML] Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation
…, B Gréco, RH van Huijsduijnen, PF Zaratin - Journal of …, 2010 - Springer
Background PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on
immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting …
immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting …
[HTML][HTML] Knockout mice reveal a role for protein tyrosine phosphatase H1 in cognition
…, M Ardizzone, V Muzio, B Gréco, PF Zaratin - Behavioral and Brain …, 2008 - Springer
Background The present study has investigated the protein tyrosine phosphatase H1 (PTPH1)
expression pattern in mouse brain and its impact on CNS functions. Methods We have …
expression pattern in mouse brain and its impact on CNS functions. Methods We have …
Disease‐modifying therapies and coronavirus disease 2019 severity in multiple sclerosis
…, M Capobianco, M Trojano, P Zaratin… - Annals of …, 2021 - Wiley Online Library
Objective This study was undertaken to assess the impact of immunosuppressive and
immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID‐19) in people …
immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID‐19) in people …