Stapled α−helical peptides have emerged as a promising new modality for a wide range of
therapeutic targets. Here, we report a potent and selective dual inhibitor of MDM2 and MDMX…

It is hypothesized that the principal features of higher plant distributions at continental scales
are determined by the macroclimate. Bioclimate data have been computed on a 50 km grid …

Objective: To validate a diagnostic instrument for pediatric delirium in critically ill children,
both ventilated and nonventilated, that uses standardized, developmentally appropriate …

Plant species have responded to recent increases in global temperatures by shifting their
geographical ranges poleward and to higher altitudes. Bioclimate models project future range …

Aim: To explore patient and physician descriptions of COPD attributes, in order to inform
content development of a patient-reported clinical assessment tool. Methods: Qualitative …

Background The COPD Assessment Test (CAT) is an eight-item questionnaire suitable for
routine clinical use that shows reliability and validity in stable and exacerbating COPD. …

Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF
receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic …

Mountain ecosystems are often identified as being particularly sensitive to climate change,
however this has rarely been investigated at the scale of individual mountain ranges using …

This paper describes the rationale and goals of the Patient-Reported Outcome (PRO)
Consortium’s instrument translation process. The PRO Consortium has developed a number of …

Objective Evaluate the efficacy and safety of ustekinumab, an anti-interleukin-12/23 p40
antibody, in a phase 3, randomised, placebo-controlled study of patients with active systemic …