Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the …

Objective. To study the influence of anti-tumor necrosis factor-α (TNF-α) treatment on
echocardiographic measures and concentrations of endothelin 1 (ET-1), interleukin 6 (IL-6), and …

The Janus Kinases (JAKs) are a family of intracellular tyrosine kinases that provide
transmission signals from cytokine, interferons, and many hormones receptors to the nucleus …

Recent advances in immunology enabled the characterization of several signal transmitting
pathways responsible for proper cytokine and chemokine signaling. Among them, Janus …

Janus kinase (JAK) inhibitors, a novel class of targeted synthetic disease-modifying
antirheumatic drugs (DMARDs), have shown their safety and efficacy in rheumatoid arthritis (RA) …

Treatment with anti-TNF-α (tumor necrosis factor), one of the pivotal cytokines, was
introduced to clinical practice at the end of last century and revolutionized the treatment of …

Behçet’s disease (BD) is a multifactorial systemic inflammatory disease of unknown aetiology
characterised by several clinical manifestations including vascular involvements (i.e., both …

Background: Ferritin is a molecule that plays many roles being the storage for iron, signalling
molecule, and modulator of the immune response. Methods: Different electronic databases …

Systemic sclerosis, a connective tissue disease, is characterized by thickening of the skin,
massive fibrosis of internal organs, vasculopathy, and immune system functioning aberration. …

Systemic sclerosis (SSc) is a connective tissue disease that is characterized by widespread
skin and internal organ fibrosis vasculopathy and immune response abnormalities, including …