Increased activity of T follicular helper (Tfh) cells plays a major pathogenic role in systemic
lupus erythematosus (SLE). However, the mechanisms that cause aberrant Tfh cell responses …

Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease
characterized by the involvement of multiple organs and an immune response against nuclear …

T follicular helper (Tfh) cells are a distinct subset of CD4 + T lymphocytes, specialized in B
cell help and in regulation of antibody responses. They are required for the generation of …

Objectives No immunomodulatory drug has been approved for primary Sjögren’s syndrome,
a systemic autoimmune disease affecting 0.1% of the population. To demonstrate the …

Extracellular vesicles (EVs) consist of exosomes released upon fusion of multivesicular bodies
with the cell plasma membrane and microparticles shed directly from the cell membrane …

As part of the Immunological Genome Project (ImmGen), gene expression was determined in
unstimulated (circulating) mouse neutrophils and three populations of neutrophils activated …

Objective Our aim was to assess the real‐world effectiveness of immune checkpoint inhibitors
for treatment of patients with progressive multifocal leukoencephalopathy (PML). Methods …

Objectives. The aim was to assess the immunogenicity and the impact on disease activity of
pneumococcal and influenza vaccines in SLE patients. Methods. We conducted a systematic …

Background Bevacizumab, an anti-VEGF monoclonal antibody, has recently emerged as a
new option for severe forms of hereditary hemorrhagic telangiectasia (HHT). Its utilization in …

Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are two phenotypically
distincts inflammatory systemic diseases. However, SLE and SSc share pathogenic features …