Glycosylation and the immune system

PM Rudd, T Elliott, P Cresswell, IA Wilson, RA Dwek - Science, 2001 - science.org
Almost all of the key molecules involved in the innate and adaptive immune response are
glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding, …

The impact of glycosylation on the biological function and structure of human immunoglobulins

JN Arnold, MR Wormald, RB Sim, PM Rudd… - Annu. Rev …, 2007 - annualreviews.org
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number, …

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

…, R Pantophlet, MB Zwick, GM Morris, PM Rudd… - science, 2001 - science.org
We present the crystal structure at 2.7 angstrom resolution of the human antibody IgG1 b12.
Antibody b12 recognizes the CD4-binding site of human immunodeficiency virus–1 (HIV-1) …

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)

…, B Dubois, I Nelissen, PM Rudd… - Critical reviews in …, 2002 - Taylor & Francis
The matrix metalloproteinases (MMPs) form an enzyme family of which gelatinase B (MMP-9)
represents the largest and most complex member. We focus here on the biochemical …

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

…, RL Stanfield, KH Roux, JW Kelly, PM Rudd… - Science, 2003 - science.org
Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1 (HIV-1)
isolates by binding an unusually dense cluster of carbohydrate moieties on the “silent” …

Concepts and principles of O-linked glycosylation

PV Steen, PM Rudd, RA Dwek… - Critical reviews in …, 1998 - Taylor & Francis
The biosynthesis, structures, and functions of O-glycosylation, as a complex posttranslational
event, is reviewed and compared for the various types of O-glycans. Mucin-type O-…

Glycosylation changes of IgG associated with rheumatooid arthritis can activate complement via the mannose-binding protein

R Malhotra, MR Wormald, PM Rudd, PB Fischer… - Nature medicine, 1995 - nature.com
The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in
rheumatoid arthritis. The extent of the changes correlates with the disease severity and …

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of α1→ 2 mannose residues on the outer face of gp120

…, IA Wilson, H Katinger, RA Dwek, PM Rudd… - Journal of …, 2002 - Am Soc Microbiol
2G12 is a broadly neutralizing human monoclonal antibody against human immunodeficiency
virus type-1 (HIV-1) that has previously been shown to bind to a carbohydrate-dependent …

A systematic approach to protein glycosylation analysis: a path through the maze

K Marino, J Bones, JJ Kattla, PM Rudd - Nature chemical biology, 2010 - nature.com
Protein glycosylation is an important post-translational modification. It is a feature that enhances
the functional diversity of proteins and influences their biological activity. A wide range …

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

…, IR Mehlhorn, G Legname, MR Wormald, PM Rudd… - Nature, 2001 - nature.com
Prions are the transmissible pathogenic agents responsible for diseases such as scrapie
and bovine spongiform encephalopathy. In the favoured model of prion replication, direct …