Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in
women. It has traditionally been classified as either a musculoskeletal disease or a …

Fibromyalgia is characterized by chronic widespread pain and bodily tenderness and is often
accompanied by affective disturbances. Accumulating evidence indicates that fibromyalgia …

Recent insights have demonstrated a central role for dopaminergic neurotransmission in
modulating pain perception and natural analgesia within supraspinal regions, including the …

Although the pathophysiology underlying the pain of fibromyalgia syndrome (FMS) remains
unknown, a variety of clinical and investigational findings suggests a dysregulation of …

Fibromyalgia has been called a “stress-related disorder” due to the onset and exacerbation
of symptoms in the context of stressful events. Evidence suggests that inhibition of tonic pain …

Dopaminergic neurons of the mesolimbic system originate from cell bodies within the ventral
tegmental area (VTA) and project primarily to the ventral striatum/nucleus accumbens (NAc)…

Fibromyalgia (FM) has been associated with alterations in brain morphometry and abnormal
dopaminergic neurotransmission. Evidence from preclinical models has demonstrated that …

Although the pathology of fibromyalgia is poorly understood, a growing body of evidence
suggests involvement of the central nervous system. The hippocampus is a brain center that is …

Background: Recent evidence points to the likelihood of heterogeneity in the presentation
and, perhaps, etiology offibromyalgia (FM). A clearer understanding of the symptomatology …

BACKGROUND Evidence suggests that fibromyalgia is related to both chronic sympathetic
hyperactivity and decreased levels of serotonin. OBJECTIVE To examine the efficacy of …