Background Hereditary transthyretin amyloidosis is caused by pathogenic single-nucleotide
variants in the gene encoding transthyretin (TTR) that induce transthyretin misfolding and …

The clinical course of 40 patients with significant quantities of mixed cryoglobulins, but without
lymphoproliferative, collagen-vascular or chronic infectious diseases, is presented. These …

Importance Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation
of variant transthyretin, induces progressive peripheral nerve deficits and disability. …

In view of a high frequency of liver involvement in patients with essential mixed cryoglobulinemia,
we looked for evidence for hepatitis B virus infection in 25 serum specimens and 19 …

Background Amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions
that develops when proteolytic fragments of serum amyloid A protein (SAA) are deposited …

In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association
cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex…

Curvilinear fibrils with the tinctorial properties of amyloid were isolated from a patient with
bone and joint involvement complicating chronic dialysis for renal disease. Subunit fractions of …

Objective: To review autoimmune disease complicating therapy with type I interferons (IFNs),
specifically in the setting of hepatitis C virus (HCV) infection. Methods: This study describes …

This guideline provides the recommendations of an expert panel for the clinical and
laboratory evaluation of patients suspected of having a clinical condition that produces a …

Cryoglobulins are immunoglobulins that precipitate as serum is cooled below core body
temperatures. A cryoglobulin screen is the observation of a serum specimen collected and …