Rheumatoid arthritis results from a T cell-driven inflammation in the synovial membrane that
is frequently associated with the formation of tertiary lymphoid structures. The significance of …

… All tissue samples were reviewed by one pathologist (J. Bjornsson) whowas unaware of
any clinical, serological, or immunohistological findings. To control for patchiness of the …

Giant cell arteritis (GCA) is a systemic vasculitis preferentially affecting large and medium-sized
arteries. Inflammatory infiltrates in the arterial wall induce luminal occlusion with …

… PA Klimiuk1, … Kuryliszyn-Moskal A, Bernacka K, Klimiuk PA. Circulating intercellular
adhesion molecule 1 in rheumatoid arthritis - relationship to systemic vasculitis and microvascular …

Systemic sclerosis (SSc) is a chronic, multisystemic, autoimmune disease characterised by
vascular changes and varying degrees of fibrosis of the skin and visceral organs. Organ …

… Piotr A Klimiuk3, … system; Almac Clinical Technologies, Souderton, Pennsylvania, USA)
included stratification according to region (Asia, EU, Latin America, USA) and prior exposure to a …

In rheumatoid arthritis, T lymphocytes have been proposed to play a pivotal role in the disease
process, but they have also been considered to simply represent an epiphenomenon in a …

Objective: To evaluate long-term safety, efficacy, and immunogenicity of BI 695501 in
patients with moderately-to-severely active rheumatoid arthritis (RA) who have completed …

… that patients with rheumatoid factor (RF)-negative (seronegative) RA were characterized
by an enrichment of both the HLA-DRB 1"04 and *01 alleles [65]. In contrast, 90% of patients …

Thrombospondin-1 (TSP) is a transiently expressed matricellular protein known to promote
chemotaxis of leukocytes to inflammatory sites. However, TSP and its receptor CD36 are …