Principal components analysis corrects for stratification in genome-wide association studies
…, NJ Patterson, RM Plenge, ME Weinblatt, NA Shadick… - Nature …, 2006 - nature.com
Population stratification—allele frequency differences between cases and controls due to
systematic ancestry differences—can cause spurious associations in disease studies. We …
systematic ancestry differences—can cause spurious associations in disease studies. We …
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
…, DM Reid, M Seielstad, MF Seldin, NA Shadick… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397
individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in …
individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in …
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
…, D Altshuler, TWJ Huizinga, NA Shadick… - Nature …, 2008 - nature.com
To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis
of two published genome-wide association (GWA) studies totaling 3,393 cases and …
of two published genome-wide association (GWA) studies totaling 3,393 cases and …
HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software
…, JL Abrahams, YG Kim, GW Henry, NA Shadick… - Analytical …, 2008 - Elsevier
We present a robust, fully automatable technology platform that includes computer software
for the detailed analysis of low femtomoles of N-linked sugars released from glycoproteins. …
for the detailed analysis of low femtomoles of N-linked sugars released from glycoproteins. …
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot
Tetralogy of Fallot (TOF), the most common severe congenital heart malformation, occurs
sporadically, without other anomaly, and from unknown cause in 70% of cases. Through a …
sporadically, without other anomaly, and from unknown cause in 70% of cases. Through a …
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
…, DM Reid, M Seielstad, MF Seldin, NA Shadick… - Nature …, 2009 - nature.com
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …
The long-term clinical outcomes of Lyme disease: a population-based retrospective cohort study
NA Shadick, CB Phillips, EL Logigian… - Annals of Internal …, 1994 - acpjournals.org
Objective: To ascertain the prevalence of and risk factors for long-term sequelae from acute
Lyme disease. Design: Population-based, retrospective cohort study. Setting: A coastal …
Lyme disease. Design: Population-based, retrospective cohort study. Setting: A coastal …
The natural history of exercise-induced anaphylaxis: survey results from a 10-year follow-up study
Background: Exercise-induced anaphylaxis (EIA) is a unique physical allergy that is triggered
by exertion, the clinical spectrum and modifying factors of which have been previously …
by exertion, the clinical spectrum and modifying factors of which have been previously …
[HTML][HTML] Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study
…, B Lu, ML Frits, CK Iannaccone, NA Shadick… - Arthritis research & …, 2011 - Springer
Introduction Disease remission has become a feasible goal for most rheumatoid arthritis (RA)
patients; however, patient-reported symptoms, such as pain, may persist despite remission…
patients; however, patient-reported symptoms, such as pain, may persist despite remission…