Principal components analysis corrects for stratification in genome-wide association studies

…, NJ Patterson, RM Plenge, ME Weinblatt, NA Shadick… - Nature …, 2006 - nature.com
Population stratification—allele frequency differences between cases and controls due to
systematic ancestry differences—can cause spurious associations in disease studies. We …

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

…, DM Reid, M Seielstad, MF Seldin, NA Shadick… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

…, S Purcell, L Klareskog, PK Gregersen, NA Shadick… - Nature …, 2007 - nature.com
To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397
individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in …

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

…, D Altshuler, TWJ Huizinga, NA Shadick… - Nature …, 2008 - nature.com
To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis
of two published genome-wide association (GWA) studies totaling 3,393 cases and …

HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software

…, JL Abrahams, YG Kim, GW Henry, NA Shadick… - Analytical …, 2008 - Elsevier
We present a robust, fully automatable technology platform that includes computer software
for the detailed analysis of low femtomoles of N-linked sugars released from glycoproteins. …

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

…, MA Artunduaga, RD Eavey, RM Plenge, NA Shadick… - Nature …, 2009 - nature.com
Tetralogy of Fallot (TOF), the most common severe congenital heart malformation, occurs
sporadically, without other anomaly, and from unknown cause in 70% of cases. Through a …

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

…, DM Reid, M Seielstad, MF Seldin, NA Shadick… - Nature …, 2009 - nature.com
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …

The long-term clinical outcomes of Lyme disease: a population-based retrospective cohort study

NA Shadick, CB Phillips, EL Logigian… - Annals of Internal …, 1994 - acpjournals.org
Objective: To ascertain the prevalence of and risk factors for long-term sequelae from acute
Lyme disease. Design: Population-based, retrospective cohort study. Setting: A coastal …

The natural history of exercise-induced anaphylaxis: survey results from a 10-year follow-up study

NA Shadick, MH Liang, AJ Partridge, C Bingham… - Journal of allergy and …, 1999 - Elsevier
Background: Exercise-induced anaphylaxis (EIA) is a unique physical allergy that is triggered
by exertion, the clinical spectrum and modifying factors of which have been previously …

[HTML][HTML] Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study

…, B Lu, ML Frits, CK Iannaccone, NA Shadick… - Arthritis research & …, 2011 - Springer
Introduction Disease remission has become a feasible goal for most rheumatoid arthritis (RA)
patients; however, patient-reported symptoms, such as pain, may persist despite remission…