Patients with limited cardiac reserve are less likely to survive and develop more complications
following major surgery. By augmenting oxygen delivery index (DO 2 I) with a combination …

Introduction: The P2X7 receptor (P2X7R) has an important role in inflammation and immunity,
but until recently, clinical application has been limited by a lack of specific antagonists. …

Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare.
Current studies of such ‘double-positive’ cases report small numbers and variable outcomes. …

Mitochondria are an essential part of the cellular infrastructure, being the primary site for
high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in …

Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal
frameworks. Recreating the complexity of cytoskeletal and exoskeletal fibers, with their …

Objectives. ANCA-associated vasculitis and interstitial lung disease (ILD) are uncommon
conditions. The occurrence of both diseases in the same patient is increasingly recognized. …

Purpose Interleukin-6 (IL-6) levels discriminate between patients with mild and severe
COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a systematic …

The potential for transmission of coronavirus disease 2019 (COVID-19) from patients to
health-care workers has caused concern, particularly among patients requiring advanced …

The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials
outweighs any potential harm is a significant barrier to improved stewardship of these …

Purpose The integration of palliative care into intensive care units (ICUs) is advocated to
mitigate physical and psychological burdens for patients and their families, and to improve end-…