Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

Knee-replacement surgery is frequently done and highly successful. It relieves pain and
improves knee function in people with advanced arthritis of the joint. The most common …

Although vertebral deformities are known to predict future vertebral deformities, little is
known about their ability to predict other osteoporotic fractures. We examined the association …

Objectives Data on the incidence of symptomatic osteoarthritis (OA) are scarce. We estimated
incidence of clinical hip, knee and hand OA, and studied the effect of prevalent OA on joint-…

Background Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective
and demonstrate significant clinical improvement. However, robust population …

… Author links open overlay panel Olivier Bruyère a b , Germain Honvo a b , Nicola Veronese
c , Nigel K. Arden d e , Jaime Branco f , Elizabeth M. Curtis e , Nasser M. Al-Daghri g , Gabriel …

Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on
quality of life, and its clinical management is difficult. Among the several available guidelines …

Lean body mass and muscle strength are both associated with bone mineral density (BMD),
which is known to be under strong genetic control. In this classical twin study, we examine …

Osteoarthritis (OA) has been thought of as a disease of cartilage that can be effectively
treated surgically at severe stages with joint arthroplasty. Today, OA is considered a whole-organ …

Objective Studies of previous cohorts have demonstrated an association between a status
of overweight/obesity and the presence of knee and hand osteoarthritis (OA). However, no …