Griscelli syndrome (GS, MIM 214450), a rare, autosomal recessive disorder, results in
pigmentary dilution of the skin and the hair, the presence of large clumps of pigment in hair shafts …

Background Systemic juvenile idiopathic arthritis (JIA) is the most severe subtype of JIA;
treatment options are limited. Interleukin-6 plays a pathogenic role in systemic JIA. Methods We …

Objective To develop criteria for the classification of macrophage activation syndrome (MAS)
in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process, …

Background Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis
(JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti–…

To update the European League Against Rheumatism (EULAR) recommendations for vaccination
in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published …

Objective To compare the safety and efficacy of parenteral methotrexate (MTX) at an intermediate
dosage (15 mg/m 2 /week) versus a higher dosage (30 mg/m 2 /week) in patients with …

Objective To analyze which physiologic stimuli induce secretion of myeloid‐related protein
8 (MRP8) and MRP14, two S100 proteins expressed in neutrophils and monocytes, and to …

Objective To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid
arthritis (JRA). Methods This was an international, multicenter, randomized, placebo‐…

BACKGROUND: Hematopoietic stem cell transplantation remains the only treatment for
most patients with severe combined immunodeficiencies (SCIDs) or other primary …

Background: Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of disorders
with, for the most part, an unknown immunopathogenesis. Although onset and disease …