Objective: We have previously isolated cardiomyogenic cells from murine bone marrow (CMG
cells). Regenerated cardiomyocytes are important candidates for cell transplantation, but …

Ischemic injury to the kidney results in blood vessel loss and predisposition to chronic renal
disease. Angiostatin is a proteolytic cleavage product of plasminogen that inhibits …

Bone marrow mesenchymal stem cells (CMG cells) are multipotent and can be induced by 5-azacytidine
to differentiate into cardiomyocytes. We characterized the electrophysiological …

The metabolic syndrome (MS), a condition characterized by several risk factors for coronary
artery disease, including obesity, is associated with endothelial dysfunction and oxidative …

For therapeutic angiogenesis to achieve clinical relevance, it must be effective, with minimal
side effects to other end organ systems. We developed a cardiac-specific gene delivery …

Objectives: Restoration of coronary blood flow by angiogenesis may offer a new approach
to intractable ischemic heart disease. In the present study, we investigated the angiogenic …

The control of coronary blood flow has been studied for decades, but despite our extensive
efforts, the critical regulators of flow are largely unknown. One purpose of this review is to …

Hemoperfusion with a column of polymyxin B immobilized on fibers (PMX) has been used to
adsorb endotoxin in-patients with septic shock. PMX hemoperfusion (PMX-H) increases …

We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia
by increasing regional perfusion via the transmural channels in acute canine experiments. …

To clarify the pathophysiological cascade leading to lipopolysaccharide-(LPS) induced
myocardial dysfunction, we measured sarcoplasmic reticulum (SR) function, expression of …