Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia, which …

Objective Existing criteria for the classification of gout have suboptimal sensitivity and/or
specificity, and were developed at a time when advanced imaging was not available. The …

In response to a request for proposal from the American College of Rheumatology (ACR), our
group was charged with developing nonpharmacologic and pharmacologic guidelines for …

Context Patients with chronic disabling gout refractory to conventional urate-lowering
therapy need timely treatment to control disease manifestations related to tissue urate crystal …

The human immunodeficiency virus (HIV‐1) long terminal repeat (LTR) contains two binding
sites for NF‐kappa B in close proximity to three binding sites for the constitutive transcription …

Elevated serum urate levels are recognized as leading to gouty arthritis, tophi formation, and
uric acid kidney stones. While serum urate elevations have long been associated with renal …

Uric acid has been long recognized as the cause of gouty arthritis and kidney stones. There
is mounting evidence that it may also have an important role in the development of vascular …

Background: Gout is a painful and disabling inflammatory arthritis of increasing prevalence
associated with hyperuricemia and the deposition of monosodium urate crystals in soft …

• Occasionally patients with overlapping features of rheumatoid arthritis (RA) and systemic
lupus erythematosus (SLE), termed "rhupus," have been encountered. We wanted to …

Methods We identified and investigated 13 patients with lympho-or myeloproliferative
disorders and associated vasculitis seen between 1970 and 1987. We performed the following …