Background The advent of bisphosphonates advanced therapy for Paget's disease, but
more effective and convenient agents are needed to increase adherence. Zoledronic acid, a …

Objectives To investigate baricitinib (LY3009104, formerly INCB028050), a novel, oral
inhibitor of JAK1/JAK2 in patients with moderate to severe rheumatoid arthritis (RA) despite …

Objective Magnetic resonance imaging (MRI) and radiography are established imaging
modalities for the assessment of knee osteoarthritis (OA). The objective of our study was to …

Objective: The performance characteristics of hyaline articular cartilage measurement on
magnetic resonance imaging (MRI) need to be accurately delineated before widespread …

Background: Chronic plaque psoriasis is partially mediated by elevation of proinflammatory
cytokines, including several within the Janus kinase/signal transducer and activator of …

Introduction: In rheumatoid arthritis (RA) there is a significant medical need for safe and
effective oral disease-modifying anti-rheumatic drugs (DMARDs) for patients who respond …

Objective. We report an unusual case of primary pulmonary hypertension and review the
pertinent literature. Methods. A 25‐year‐old Caucasian woman presented with progressive …

Objective. Magnetic resonance imaging (MRI) was used in a phase IIb study of baricitinib in
patients with RA to support dose selection for the phase III program. Methods. Three …

Synovial tissue is rarely available from patients with early synovitis, with the exception of
synovial biopsies. However, T cell populations early in the development of synovitis may be …

METHODS This study examined the baseline and 12 month visits of a subset of 150 subjects
from the OAI. Measurement of radiographic JSW was facilitated by the use of automated …