Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

RC Billinghurst, L Dahlberg, M Ionescu… - The Journal of …, 1997 - Am Soc Clin Investig
We demonstrate the direct involvement of increased collagenase activity in the cleavage of
type II collagen in osteoarthritic human femoral condylar cartilage by developing and using …

Evidence for altered synthesis of type II collagen in patients with osteoarthritis.

…, A Reiner, I Pidoux, M Ionescu… - The Journal of …, 1998 - Am Soc Clin Investig
There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis
(OA). Using an immunoassay, we show that the content of the C-propeptide of type II …

Changes in joint cartilage aggrecan after knee injury and in osteoarthritis

LS Lohmander, M Ionescu, H Jugessur… - … : Official Journal of the …, 1999 - Wiley Online Library
Objective To determine the concentrations of aggrecan fragments in synovial fluid from
patients with knee joint injury, osteoarthritis (OA), or acute pyrophosphate arthritis (PPA; …

Selective enhancement of collagenase‐mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that …

…, F Nelson, G Webb, M Ionescu… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To examine whether type II collagen cleavage by collagenase and loss of
proteoglycan are excessive in human osteoarthritic (OA) articular cartilage compared with …

The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis

GR Squires, S Okouneff, M Ionescu… - Arthritis & …, 2003 - Wiley Online Library
Objective To determine if early focal lesions seen in aging exhibit molecular changes in the
extracellular matrix that are similar to those seen in osteoarthritis (OA) and to examine the …

Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis

JR Matyas, L Atley, M Ionescu… - … : Official Journal of the …, 2004 - Wiley Online Library
Objective To study 3 body fluids for changes in the levels of 5 biomarkers of cartilage metabolism
during the early phases of experimental osteoarthritis (OA). Methods Twenty skeletally …

Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local …

…, U Fearon, RC Billinghurst, M Ionescu… - Arthritis & …, 2003 - Wiley Online Library
Objective To determine in vivo the extent of damage to, and changes in turnover of, articular
cartilage type II collagen (CII) and the proteoglycan aggrecan following the onset of …

Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis

…, J Sampalis, L Moquin, M Ionescu… - Arthritis & …, 2005 - Wiley Online Library
Objective To determine whether oral glucosamine alleviates cartilage degradation in an
animal model of osteoarthritis (OA). Methods The effect of 8 weeks of daily oral glucosamine …

The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases

AR Poole, M Ionescu, MA Fitzcharles… - Journal of …, 2004 - Elsevier
A monoclonal antibody has been developed which recognizes a neoepitope in type II collagen
which is generated by the intrahelical cleavage of collagenases. Antibody reactivity is …

Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage

…, LC Rosenberg, A Reiner, M Ionescu… - Journal of …, 1996 - Wiley Online Library
The study was designed to determine the contents and distributions of the proteoglycans
decorin and biglycan in adult human femoral condylar cartilage and whether these may change …