Background We conducted a double-blind, randomized, placebo-controlled trial to determine
the effects of oral cyclophosphamide on lung function and health-related symptoms in …

Background 12 months of oral cyclophosphamide has been shown to alter the progression
of scleroderma-related interstitial lung disease when compared with placebo. However, …

Purpose: We previously reported that autologous dendritic cells pulsed with acid-eluted tumor
peptides can stimulate T cell–mediated antitumor immune responses against brain tumors …

Rationale: The Scleroderma Lung Study enrolled 158 patients with scleroderma-related
interstitial lung disease in a placebo-controlled trial of oral cyclophosphamide (CYC). Although …

The ability of dendritic cells (DC) to initiate immune responses in naive T cells is dependent
upon a maturation process that allows the cells to develop their potent Ag-presenting …

The diverse roles of interferon‐α (IFN‐α) in regulating the immune response to infectious
agents suggested that it might affect dendritic cell (DC) development. Peripheral blood …

Background Marijuana and alkaloidal cocaine (“crack”) are the two most commonly smoked
substances in the United States after tobacco. While regular tobacco smoking has been …

In this study, we show that Δ-9-tetrahydrocannabinol (THC), the major psychoactive component
of marijuana, suppresses host immune reactivity against lung cancer. In two different …

… Correspondence and requests for reprints should be addressed to Michael D. Roth, MD,
Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, …

Use of marijuana and cocaine is on the rise in the United States. Although pulmonary toxicity
from these drugs has occasionally been reported, little is known about their effects on the …