User profiles for Merry-Lynn McDonald

Merry-Lynn Noelle McDonald

Associate Professor, University of Alabama at Birmingham
Verified email at uab.edu
Cited by 4432

The clinical and genetic features of COPD-asthma overlap syndrome

M Hardin, M Cho, ML McDonald, T Beaty… - European …, 2014 - Eur Respiratory Soc
Individuals with chronic obstructive pulmonary disease (COPD) and asthma are an important
but poorly characterised group. The genetic determinants of COPD and asthma overlap …

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

…, N Laird, C Lange, SM Lutz, ML McDonald… - Journal of allergy and …, 2018 - Elsevier
Background Eosinophilic airway inflammation in patients with chronic obstructive pulmonary
disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting …

[HTML][HTML] A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

…, K Young, CP Hersh, PJ Castaldi, ML McDonald… - BMC genetics, 2015 - Springer
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1 /FVC ratio are considered the standard …

[HTML][HTML] The Chicken Frizzle Feather Is Due to an α-Keratin (KRT75) Mutation That Causes a Defective Rachis

CS Ng, P Wu, J Foley, A Foley, ML McDonald… - PLoS …, 2012 - journals.plos.org
Feathers have complex forms and are an excellent model to study the development and
evolution of morphologies. Existing chicken feather mutants are especially useful for identifying …

Potential role of modifier genes influencing transforming growth factor-β1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary …

A Bourdeau, ME Faughnan, ML McDonald… - The American journal of …, 2001 - Elsevier
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder because
of mutations in the genes coding for endoglin (HHT1) or ALK-1 (HHT2). The disease is …

Machine learning characterization of COPD subtypes: insights from the COPDGene study

…, BD Hobbs, N Laird, C Lange, SM Lutz, ML McDonald… - Chest, 2020 - Elsevier
COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …

Chest CT measures of muscle and adipose tissue in COPD: gender-based differences in content and in relationships with blood biomarkers

AA Diaz, L Zhou, TP Young, ML McDonald… - Academic radiology, 2014 - Elsevier
Rationale and Objectives Computed tomography (CT) of the chest can be used to assess
pectoralis muscle area (PMA) and subcutaneous adipose tissue (SAT) area. Adipose tissue …

[HTML][HTML] Pectoralis muscle area and mortality in smokers without airflow obstruction

…, R Harmouche, TP Young, ML McDonald… - Respiratory …, 2018 - Springer
Background Low muscle mass is associated with increased mortality in the general population
but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is …

The St. George's Respiratory Questionnaire definition of chronic bronchitis may be a better predictor of COPD exacerbations compared with the classic definition

…, N Laird, C Lange, SM Lutz, ML McDonald… - Chest, 2019 - Elsevier
Background Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown
that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients …

Lobar emphysema distribution is associated with 5-year radiological disease progression

…, N Hansel, C Hersh, P Castaldi, ML McDonald… - Chest, 2018 - Elsevier
Background Emphysema has considerable variability in its regional distribution. Craniocaudal
emphysema distribution is an important predictor of the response to lung volume reduction…