On the alert for cytokine storm: immunopathology in COVID‐19
…, R Caricchio, S Mahmud, MM Hazen… - Arthritis & …, 2020 - Wiley Online Library
Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …
[HTML][HTML] Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children
…, O Halyabar, JS Hausmann, MM Hazen… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Pediatric SARS–CoV-2 infection can be complicated by a dangerous
hyperinflammatory condition termed multisystem inflammatory syndrome in children (MIS-C). The …
hyperinflammatory condition termed multisystem inflammatory syndrome in children (MIS-C). The …
Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis
…, DEW Chatterton, KD Deane, MM Hazen… - Arthritis & …, 2010 - Wiley Online Library
Objective To examine the association between aberrant IgG galactosylation and disease
parameters in rheumatoid arthritis (RA). Methods Analysis of N‐glycan in serum samples from …
parameters in rheumatoid arthritis (RA). Methods Analysis of N‐glycan in serum samples from …
Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis
…, J Antón, PR Blier, V Gerloni, MM Hazen… - Arthritis care & …, 2013 - Wiley Online Library
Objective Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and
arthritis, for which interleukin‐1 (IL‐1) and IL‐6 inhibitors appear to be effective treatments. …
arthritis, for which interleukin‐1 (IL‐1) and IL‐6 inhibitors appear to be effective treatments. …
Mutations of the hemophagocytic lymphohistiocytosis–associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis
MM Hazen, AL Woodward, I Hofmann… - … : Official Journal of …, 2008 - Wiley Online Library
The clinical syndromes of hemophagocytic lymphohistiocytosis (HLH) and macrophage
activation syndrome (MAS) are both characterized by dysregulated inflammation with prolonged …
activation syndrome (MAS) are both characterized by dysregulated inflammation with prolonged …
[HTML][HTML] Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage …
…, T Banerjee, F Dedeoglu, BA Degar, MM Hazen… - Pediatric …, 2019 - Springer
Background Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome
(MAS) were historically thought to be distinct entities, often managed in isolation. In fact, …
(MAS) were historically thought to be distinct entities, often managed in isolation. In fact, …
[HTML][HTML] Outcomes and treatment strategies for autoimmunity and hyperinflammation in patients with RAG deficiency
…, MM Eibl, HM Wolf, LA Henderson, MM Hazen… - The Journal of Allergy …, 2019 - Elsevier
Background Although autoimmunity and hyperinflammation secondary to recombination
activating gene (RAG) deficiency have been associated with delayed diagnosis and even death…
activating gene (RAG) deficiency have been associated with delayed diagnosis and even death…
[HTML][HTML] Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis
…, MH Chang, EM Cohen, F Dedeoglu, MM Hazen… - JCI insight, 2021 - ncbi.nlm.nih.gov
Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic
inflammatory arthritis in children, yet the cause of this disease remains unknown. To understand …
inflammatory arthritis in children, yet the cause of this disease remains unknown. To understand …
Incidence and risk factors for eosinophilia and lung disease in biologic‐exposed children with systemic juvenile idiopathic arthritis
…, O Halyabar, JS Hausmann, MM Hazen… - Arthritis Care & …, 2023 - Wiley Online Library
Objective Although interleukin‐1 (IL‐1)/IL‐6 inhibitors are effective therapies for systemic
juvenile idiopathic arthritis (JIA), some patients develop eosinophilia and lung disease during …
juvenile idiopathic arthritis (JIA), some patients develop eosinophilia and lung disease during …
[HTML][HTML] Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis
…, F Dedeoglu, RC Fuhlbrigge, O Halyabar, MM Hazen… - JCI insight, 2020 - ncbi.nlm.nih.gov
Systemic juvenile idiopathic arthritis (sJIA) begins with fever, rash, and high-grade systemic
inflammation but commonly progresses to a persistent afebrile arthritis. The basis for this …
inflammation but commonly progresses to a persistent afebrile arthritis. The basis for this …