Bone remodeling depends on the precise coordination of bone resorption and subsequent
bone formation. Disturbances of this process are associated with skeletal diseases, such as …

Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical
therapy for the condition because of limited understanding of its pathogenesis. We show …

Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent
study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (…

Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix,
maintains bone mass in adulthood. We now report that IGF-1 released from the bone matrix …

Development of the vertebrate skeleton, a complex biological event that includes diverse
processes such as formation of mesenchymal condensations at the sites of future skeletal …

This paper examines the value of short duration cultural festivals as tourist attractions, with
special emphasis on their role in attracting and retaining international tourists. The study …

Radiation therapy can result in bone injury with the development of fractures and often can
lead to delayed and nonunion of bone. There is no prevention or treatment for irradiation-…

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain
unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral …

Marine resources have tremendous potential for developing high-value biomaterials. The
last decade has seen an increasing number of biomaterials that originate from marine …

Intermittent administration of PTH stimulates bone formation, but the precise mechanisms
responsible for PTH responses in osteoblasts are only incompletely understood. Here we …