[HTML][HTML] Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male …

M Pierer, S Kaltenhäuser, S Arnold, M Wahle… - Arthritis research & …, 2006 - Springer
The functional single-nucleotide polymorphism (SNP) of the gene PTPN22 is a susceptibility
locus for rheumatoid arthritis (RA). The study presented here describes the association of …

[HTML][HTML] Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis

M Wahle, G Hanefeld, S Brunn, RH Straub… - Arthritis research & …, 2006 - Springer
To further understand the role of neuro-immunological interactions in the pathogenesis of
rheumatoid arthritis (RA), we studied the influence of sympathetic neurotransmitters on …

Low-dose prednisolone in rheumatoid arthritis: adverse effects of various disease modifying antirheumatic drugs

OA Malysheva, M Wahle, U Wagner, M Pierer… - The Journal of …, 2008 - jrheum.org
Objective To assess the incidence and severity of disease modifying antirheumatic drug (DMARD)-induced
adverse effects (AE) in patients with rheumatoid arthritis (RA) taking/not …

Immunopathogenesis of rheumatic diseases in the context of neuroendocrine interactions

M Wahle, A Krause, M Pierer… - Annals of the New …, 2002 - Wiley Online Library
Growing evidence supports the hypothesis that alterations of the stress response and
interactions between the neuroendocrine and immune systems contribute to the pathogenesis of …

Influence of catecholamines on cytokine production and expression of adhesion molecules of human neutrophils in vitro

M Wahle, T Greulich, CGO Baerwald, H Häntzschel… - Immunobiology, 2005 - Elsevier
The impact of catecholamines on cytokine production and expression of adhesion molecules
by human neutrophils was evaluated in vitro. Neutrophils were separated from venous …

Autonomic dysfunction in rheumatic diseases

RH Straub, CG Baerwald, M Wahle… - Rheumatic Disease …, 2005 - rheumatic.theclinics.com
Primary autonomic dysfunctions are pure autonomic failure or are caused by neurodegenerative
disorders (eg, Parkinson’s disease, multiple systems atrophy), whereas secondary …

Reduced catecholarnine response of lymphocytes from patients with rheumatoid arthritis

CGO Baerwald, M Wahle, T Ulrichs, D Jonas… - Immunobiology, 1999 - Elsevier
Catecholamines modulate lymphocyte function via stimulation of p2-adrenergic receptors (P2R).
Previous investigations revealed a decreased density of P2R on peripheral blood …

Ex vivo homeostatic proliferation of CD4+ T cells in rheumatoid arthritis is dysregulated and driven by membrane-anchored TNFα

U Wagner, M Pierer, M Wahle, F Moritz… - The Journal of …, 2004 - journals.aai.org
The systemic CD4+ T cell compartment in patients with rheumatoid arthritis (RA) is characterized
by TCR repertoire contraction, shortened telomere lengths, and decreased numbers of …

[HTML][HTML] Factor XIII and Endothelial Dysfunction in Patients with Systemic Sclerosis

S Alesci, M Wahle, A Himsel, W Miesbach - Hämostaseologie, 2023 - thieme-connect.com
Systemic sclerosis (SSc, scleroderma) is a severe autoimmune connective tissue disease
which affects the skin and internal organs. There has been evidence that coagulation factor …

Intracellular calcium responses to cholinergic stimulation of lymphocytes from healthy donors and patients with rheumatoid arthritis

A Nast, O Malysheva, A Krause, M Wahle… - Rheumatology …, 2009 - Springer
This study was performed to identify the role of cholinergic stimulation on changes of
intracellular calcium concentrations as intracellular messenger of neuroimmune interaction. …