Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of
cancer-related death in children and adolescents. Although long-term survival in localized …

Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

BACKGROUND Although there is no doubt that bisphosphonates (BPs), specific inhibitors
of osteoclasts, are beneficial for the treatment of bone metastases, their effects on visceral …

Functional and morphological alterations of the intestinal epithelial barrier (IEB) have been
consistently reported in digestive disorders such as irritable bowel syndrome and …

Patients affected by the multiple endocrine neoplasia type I syndrome (MEN1) display a high
incidence of pituitary adenomas, though it is still unknown whether these pituitary tumors …

Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency. The …

Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a
decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the …

Bone cancers are characterised by the development of tumour cells in bone sites, associated
with a dysregulation of their environment. In the last two decades, numerous therapeutic …

Objectives Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and
osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with …

Oncogenic events combined with a favourable environment are the two main factors in the
oncological process. The tumour microenvironment is composed of a complex, …