OBJECTIVE: To characterize pediatric patients who had been diagnosed with polyarteritis
nodosa (PAN) through necrotizing vasculitis of the small and mid-size arteries or those with …

BACKGROUND Undifferentiated systemic autoinflammatory diseases (USAIDs) present
diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine …

Sera from 214 healthy children and adolescents (108 females [50.4%]) aged 6 months to 20
years (mean 8.7 years) and from 116 patients with rheumatic diseases were assayed for …

Glucocorticoids (GC) are used in almost all medical specialties, and approximately 0.5% of
the general population of the United Kingdom receives those medications. With the …

Objectives: To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID)
in terms of their mechanism of action, principal indications, posology and most common …

Background Postzygotic de novo mutations lead to the phenomenon of gene mosaicism. The
3 main types are called somatic, gonadal, and gonosomal mosaicism, which differ in terms …

… The results of the partial regression coefficients demonstrated that the variable CHAQ
correlated with the physical score (t=−6.8, P=.000) and the total PedsQL 4.0 score (t=−4.3, P=.000)…

Objective To evaluate demographic data and clinical and laboratory features at disease
diagnosis in 3 different age groups of childhood‐onset systemic lupus erythematosus (SLE): …

Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers
typically cause recurring autoinflammation referred to as chronic atypical neutrophilic …

Host defense and inflammation are regulated by the NF-κB essential modulator (NEMO), a
scaffolding protein with a broad immune cell and tissue expression profile. Hypomorphic …