The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial …

CTLA4 is a cell surface molecule that shares 30% homology with CD28 and binds B7 family
members with high affinity. Analysis of surface expression on murine T cells revealed up-…

The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the
B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we …

Signalling through the B‐cell antigen receptor (BCR) is required throughout B‐cell development
and peripheral maturation. Targeted disruption of BCR components or downstream …

Engagement of the B cell antigen receptor initiates two concurrent processes, signaling and
receptor internalization. While both are required for normal humoral immune responses, the …

Within the B-cell follicle of secondary lymphoid organs, germinal center (GC) reactions produce
high affinity antibody-secreting plasma cells (PCs) and memory B-cells necessary for the …

The most prevalent severe manifestation of systemic lupus erythematosus is nephritis, which
is characterized by immune complex deposition, inflammation, and scarring in glomeruli …

The ability of B lymphocytes to capture, process and present antigens to T cells is requisite
for normal humoral immune responses and contributes to the pathogenesis of both B- and T-…

Objective In lupus nephritis, glomerular injury correlates poorly with progression to renal
failure. While the tubulointerstitium is also commonly involved, the importance of such …

During B lymphopoiesis, recombination of the locus encoding the immunoglobulin κ-chain
complex (Igk) requires expression of the precursor to the B cell antigen receptor (pre-BCR) …