Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
…, P Martin, AW Morgan, L Padyukov, MD Posthumus… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
[HTML][HTML] Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
Epidemiology and candidate gene studies indicate a shared genetic basis for celiac
disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been …
disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been …
Humoral responses after influenza vaccination are severely reduced in patients with rheumatoid arthritis treated with rituximab
…, A Holvast, CA Benne, MD Posthumus… - … : Official Journal of …, 2010 - Wiley Online Library
Objective For patients with rheumatoid arthritis (RA), yearly influenza vaccination is recommended.
However, its efficacy in patients treated with rituximab is unknown. The objectives of …
However, its efficacy in patients treated with rituximab is unknown. The objectives of …
[PDF][PDF] Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune …
Recently, association of celiac disease with common single-nucleotide polymorphism (SNP)
variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, …
variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, …
Implementation of a treat‐to‐target strategy in very early rheumatoid arthritis: results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study
…, M Hoekstra, CJ Haagsma, MD Posthumus… - Arthritis & …, 2011 - Wiley Online Library
Objective Clinical remission is the ultimate therapeutic goal in rheumatoid arthritis (RA).
Although clinical trials have proven this to be a realistic goal, the concept of targeting at …
Although clinical trials have proven this to be a realistic goal, the concept of targeting at …
Regulation of cytokine‐induced HIF‐1α expression in rheumatoid synovial fibroblasts
…, E Brouwer, R Bos, MD Posthumus… - Annals of the New …, 2007 - Wiley Online Library
The transcription factor hypoxia‐inducible factor (HIF)‐1 plays a central physiological role in
oxygen and energy homeostasis, and is activated during hypoxia by stabilization of the …
oxygen and energy homeostasis, and is activated during hypoxia by stabilization of the …
[HTML][HTML] Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease
…, CGM Kallenberg, M Bijl, MD Posthumus - Arthritis research & …, 2011 - Springer
Introduction Advanced glycation end products (AGEs) are produced and can accumulate
during chronic inflammation, as might be present in patients with rheumatoid arthritis (RA). …
during chronic inflammation, as might be present in patients with rheumatoid arthritis (RA). …
Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis
MD Posthumus, PC Limburg, J Westra, HA Cats… - …, 1999 - academic.oup.com
Objective. To evaluate the significance of serum matrix metalloproteinase-3 (MMP-3) levels
in relation to the development of radiological damage (X-ray damage) in early rheumatoid …
in relation to the development of radiological damage (X-ray damage) in early rheumatoid …
[HTML][HTML] Adherence to a treat-to-target strategy in early rheumatoid arthritis: results of the DREAM remission induction cohort
…, M Hoekstra, MD Posthumus… - Arthritis research & …, 2012 - Springer
Introduction Clinical trials have demonstrated that treatment-to-target (T2T) is effective in
achieving remission in early rheumatoid arthritis (RA). However, the concept of T2T has not …
achieving remission in early rheumatoid arthritis (RA). However, the concept of T2T has not …
The provisional ACR/EULAR definition of remission in RA: a comment on the patient global assessment criterion
…, AE van der Bijl, H Baan, MD Posthumus… - …, 2012 - academic.oup.com
Objectives. The provisional ACR/European League Against Rheumatism (EULAR) definition
of remission in RA requires a score of ≤1 on the patient global assessment (PGA, 0–10 …
of remission in RA requires a score of ≤1 on the patient global assessment (PGA, 0–10 …