The structural organization of the gene for the human cysteine-proteinase inhibitor cystatin
C was studied. Restriction-endonuclease digests of human genomic DNA hybridized with …

We investigated the mechanism of lysosome-mediated cell death using purified recombinant
pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line …

Six cysteine proteinase inhibitors were isolated from human urine by affinity chromatography
on insolubilized carboxymethylpapain followed by ion-exchange chromatography and …

Chicken egg white cystatin was first described in the late 1960s. Since then, our knowledge
about a superfamily of similar proteins present in mammals, birds, fish, insects, plants and …

The crystal structure of human cystatin C, a protein with amyloidogenic properties and a
potent inhibitor of cysteine proteases, reveals how the protein refolds to produce very tight two-…

We have investigated the inhibition of the recently identified family C13 cysteine peptidase,
pig legumain, by human cystatin C. The cystatin was seen to inhibit enzyme activity by …

A new member of the human cystatin superfamily, called cystatin E, has been found by
expressed sequence tag (EST) sequencing in amniotic cell and fetal skin epithelial cell cDNA …

Publisher Summary This chapter highlights cystatins, which are functionally active cysteine
peptidase inhibitor evolutionarily related to chicken cystatin. It focuses on human cystatins …

When an excess of human cystatin C or chicken cystatin was mixed with papain, an enzyme-inhibitor
complex was formed immediately. The residual free cystatin was then …

Estimation of kidney function is often part of daily clinical practice, mostly done by using the
endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A …