Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a
major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of …

Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts are …

Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases
including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput …

Objectives We have previously shown that peroxisome proliferator-activated receptor gamma
(PPARγ), a transcription factor, is essential for the normal growth and development of …

Fibrosis is a pathological process characterized by excessive accumulation of connective
tissue components in an organ or tissue. Fibrosis is produced by deregulated wound healing …

Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and disability,
culminating in decline in life quality. Attention has been drawn in recent years to disease…

Patients with late-stage Kellgren-Lawrence knee osteoarthritis received a single intra-articular
injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) in a …

Objective Enhanced adhesive signaling, including activation of focal adhesion kinase (FAK),
is a hallmark of fibroblasts from lung fibrosis patients, and FAK has therefore been …

Persistent myofibroblast activation distinguishes pathological fibrosis from physiological
wound healing, suggesting that therapies selectively inducing myofibroblast apoptosis could …