Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system
M Tokunaga, K Saito, D Kawabata, Y Imura… - Annals of the …, 2007 - ard.bmj.com
Aim: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious treatment-resistant
phenotype of systemic lupus erythematosus. A standard treatment for NPSLE is not …
phenotype of systemic lupus erythematosus. A standard treatment for NPSLE is not …
Low complements and high titre of anti-Sm antibody as predictors of histopathologically proven silent lupus nephritis without abnormal urinalysis in patients with …
…, K Saito, M Nawata, Y Mizuno, M Tokunaga… - …, 2015 - academic.oup.com
Objective. The aim of this study was to clarify the clinical characteristics and predictors of silent
LN (SLN), a type of LN in SLE without abnormal urinalysis or renal impairment. Methods. …
LN (SLN), a type of LN in SLE without abnormal urinalysis or renal impairment. Methods. …
Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in longterm remission after B cell depletion therapy with rituximab
S Iwata, K Saito, M Tokunaga, K Yamaoka… - The Journal of …, 2011 - jrheum.org
Objective. Rituximab has recently emerged as a novel treatment strategy for systemic lupus
erythematosus (SLE). We investigated longitudinally the differentiation and phenotypic …
erythematosus (SLE). We investigated longitudinally the differentiation and phenotypic …
[HTML][HTML] C5a promotes migration, proliferation, and vessel formation in endothelial cells
…, S Shimajiri, K Oshita, S Yukawa, M Tokunaga… - Inflammation …, 2010 - Springer
Objectives The goal of this paper is to investigate the effects of activated complement C5a
on vascular endothelium during vessel formation. Methods A human microvascular …
on vascular endothelium during vessel formation. Methods A human microvascular …
Overcoming treatment unresponsiveness mediated by P-glycoprotein overexpression on lymphocytes in refractory active systemic lupus erythematosus
S Tsujimura, K Saito, M Tokunaga… - Modern …, 2005 - Taylor & Francis
P-glycoprotein (P-gp) expels various drugs from cells, resulting in multidrug resistance, including
against glucocorticoids. Here, we present a case of systemic lupus erythematosus (SLE…
against glucocorticoids. Here, we present a case of systemic lupus erythematosus (SLE…
B cell or T cell-dominant recurrence after rituximab therapy in patients with SLE
S Iwata, K Saito, M Tokunaga, Y Tanaka - Annals of the rheumatic …, 2012 - ard.bmj.com
Systemic lupus erythematosus (SLE) is an autoimmune disease induced by autoreactive T
cell activation and B cell autoantibody overproduction. The efficacy of rituximab in refractory …
cell activation and B cell autoantibody overproduction. The efficacy of rituximab in refractory …
Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a multicenter prospective observational study
…, S Fukuyo, M Nawata, Y Miyazaki, M Tokunaga… - …, 2023 - academic.oup.com
Objective To elucidate the differential effects of biological/target synthesized DMARDs (b/tsDMARDs)
on bone metabolism in patients with rheumatoid arthritis (RA) in a real-world cohort…
on bone metabolism in patients with rheumatoid arthritis (RA) in a real-world cohort…
Efficacy of mizoribine treatment in patients with Sjögren's syndrome: an open pilot trial
…, K Nakatsuka, K Nakano, M Tokunaga… - Modern …, 2003 - academic.oup.com
The aim of this study was to evaluate the efficacy and safety of mizoribine in patients with
Sjögren’s syndrome. Forty patients with sicca syndrome, whose conditions were definitely …
Sjögren’s syndrome. Forty patients with sicca syndrome, whose conditions were definitely …
A case of rheumatoid arthritis with secondary amyloidosis in urinary bladder
…, K Nakatsuka, K Nakano, M Tokunaga… - Ryumachi …, 2002 - europepmc.org
We document a case of 61-year-old woman with a 24 year history of rheumatoid arthritis (RA),
who developed severe polyarthralgia, dry cough, paresthesia in the legs, frequent …
who developed severe polyarthralgia, dry cough, paresthesia in the legs, frequent …
Successful treatment of intravenous cyclophosphamide pulse therapy for systemic lupus erythematosus complicated with steroid-resistant hemolytic anemia
M Tokunaga, K Saito, K Nakatsuka… - Japanese Journal of …, 2003 - jstage.jst.go.jp
症例 1; 14 歳女性, 平成 13 年 5 月多関節痛, 蝶形紅斑を認め当院受診. 抗核抗体陽性, 腎障害,
溶血性貧血 (Hb 63g/dl, D-クームス (3+)), 抗 ds-DNA 抗体高値より全身性エリテマトーデス (SLE) …
溶血性貧血 (Hb 63g/dl, D-クームス (3+)), 抗 ds-DNA 抗体高値より全身性エリテマトーデス (SLE) …