Mutations of the gene encoding p62/SQSTM1 have been described in Paget’s disease of
bone (PDB), identifying p62 as an important player in osteoclast signaling. We investigated the …

Transforming growth factor-β1 (TGF-β1) is the most abundant TGF-β isoform detected in
bone and is an important functional modulator of osteoclasts. TGF-β1 can induce osteoclast …

Most of the signaling effectors located downstream of receptor activator of NF-κB (RANK)
activation are calcium-sensitive. However, the early signaling events that lead to the …

BMP-9 is a potent osteogenic factor; however, its effects on osteoclasts, the bone-resorbing
cells, remain unknown. To determine the effects of BMP-9 on osteoclast formation, activity …

The pro- and antioxidant properties of estrogens are subject of debate. The apparent
discrepancy is largely caused by the chemical heterogeneity in the estrogen family and by their …

MicroRNA (miRs) are small, non-coding RNA that post-transcriptionally regulate DNA
expression. We hypothesized that specific miR profiles may be a feature of overactive osteoclasts …

Breast cancer patients frequently develop metastases. This process requires the degradation
of extracellular matrix proteins which act as a barrier to tumour cell passage. These …

In Paget's disease of bone (PDB), a major contributory factor are osteoclasts (OCs) that are
larger, more numerous, resistant to apoptosis, and hyperactive. The aim of this human in vitro …

Background Mutations in the SQSTM1/p62 gene have been reported in Paget’s disease of
bone (PDB), but they are not sufficient to induce the pagetic osteoclast (OC) phenotype. We …

Mutations of the gene encoding sequestosome1 (SQSTM1/p62), clustering in or near the UBA
domain, have been described in Paget's disease of bone (PDB); among these the P392L …