Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

While many disease-associated variants have been identified through genome-wide association
studies, their downstream molecular consequences remain unclear. To identify these …

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Background— Studies of recurrent or subsequent disease events may be susceptible to
bias caused by selection of subjects who both experience and survive the primary indexing …

Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular
mechanism in human disease remains obscure. Here we show that circular antisense non-…

Objective— We tested the hypothesis that expression of transcripts adjacent to the chromosome
9p21 (Chr9p21) locus of coronary artery disease was affected by the genotype at this …

Background The LIFE-Adult-Study is a population-based cohort study, which has recently
completed the baseline examination of 10,000 randomly selected participants from Leipzig, a …

The chromosome 9p21 (Chr9p21) locus of coronary artery disease has been identified in the
first surge of genome-wide association and is the strongest genetic factor of atherosclerosis …

Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and
have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple …