Objective. To investigate the pathophysiological effect of interleukin 6 (IL-6) on lupus nephritis
in MRL-Fas lpr mice. Methods. We generated IL-6-deficient MRL-Fas lpr mice using a …

… Author links open overlay panel Manfred Relle a 1 , Julia Weinmann-Menke a 1 , Eva
Scorletti b , Lorenzo Cavagna b 2 , Andreas Schwarting a c 2 …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the
production of autoantibodies against nuclear antigens and a systemic inflammation that can …

Polymorphisms in the transcription factor Stat4 gene have been implicated as risk factors for
systemic lupus erythematosus. Although some polymorphisms have a strong association …

Type I interferons are associated with lupus. Genes that are regulated by IFN-α are upregulated
in pediatric lupus patients. Gene deletion of the IFN-α/β receptor in experimental lupus-…

Mast cell-deficient Kit W-sh “sash” mice are widely used to investigate mast cell functions.
However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin…

Podocin is a critical component of the glomerular filtration barrier, its mutations causing
recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (…

Granulomatosis with polyangiitis (GPA) is a severe autoimmune disease and one of the small
vessel anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although its …

Mast cells are able to trigger life-saving immune responses in murine models for acute
inflammation. In such settings, several lines of evidence indicate that the rapid and protective …

Anderson–Fabry disease, an inherited deficiency in the lysosomal enzyme α-galactosidase
A, is characterized by the progressive accumulation of globotriaosylceramide (Gb3), also …