Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …

The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic
disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify …

We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease. …

Background Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are associated
with alcohol consumption and cigarette smoking. The etiology of RAP and CP is complex, …

Background & Aims: Gain-of-function trypsin mutations cause acute pancreatitis and chronic
pancreatitis. Loss of trypsin inhibitor function may have similar effects. We investigated the …

Hereditary or primary lymphedema is a developmental disorder of the lymphatic system
which leads to a disabling and disfiguring swelling of the extremities. Hereditary lymphedema …

Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea
and gastrointestinal bleeding. We performed a genome-wide association study using DNA …

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long
thought to be the primary causative agent, but genetic contributions have been of interest …

Objectives: Studies show an increased incidence of adult acute pancreatitis (AP) in recent
decades. The aim was to review pediatric AP incidence. Methods: Retrospective review of …

Background: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are complex
syndromes associated with numerous etiologies, clinical variables and complications. We …