User profiles for M. Kristen Demoruelle

Kristen Demoruelle

University of Colorado, Anschutz Medical Campus
Verified email at ucdenver.edu
Cited by 4259

Genetic and environmental risk factors for rheumatoid arthritis

KD Deane, MK Demoruelle, LB Kelmenson… - Best practice & research …, 2017 - Elsevier
Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

…, S Liu, MD Maerz, DN Frank, MK Demoruelle… - Science translational …, 2022 - science.org
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that …

Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease

…, GP Cosgrove, MK Demoruelle… - European …, 2016 - Eur Respiratory Soc
Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis.
There is lack of clarity around predictors of mortality and disease behaviour over time in these …

Brief Report: Airways abnormalities and rheumatoid arthritis–related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?

MK Demoruelle, MH Weisman… - Arthritis & …, 2012 - Wiley Online Library
Objective To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)–related
autoantibody–positive subjects without inflammatory arthritis. Methods Forty‐two …

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease

VC Willis, MK Demoruelle, LA Derber… - Arthritis & …, 2013 - Wiley Online Library
Objective To evaluate the generation of rheumatoid arthritis (RA)–related autoantibodies in
the lung. Methods Simultaneous collection of serum and induced sputum was performed in …

When and where does inflammation begin in rheumatoid arthritis?

MK Demoruelle, KD Deane… - Current opinion in …, 2014 - journals.lww.com
Investigations are needed to determine when and where RA begins, including comprehensive
prospective studies of individuals in the preclinical period of RA that can provide insight …

Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis

…, REM Toes, TWJ Huizinga, MK Demoruelle… - The Journal of …, 2015 - jrheum.org
Objective. Anti-carbamylated protein (anti-CarP) antibodies could further elucidate early
rheumatoid arthritis (RA) pathogenesis and predict clinical disease. We compared the …

Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis

MK Demoruelle, KD Deane - Current rheumatology reports, 2012 - Springer
Data now suggest that current strategies in the treatment of rheumatoid arthritis (RA) should
focus on early identification and diagnosis, followed by early initiation of DMARD therapy. …

Anti–citrullinated protein antibodies are associated with neutrophil extracellular traps in the sputum in relatives of rheumatoid arthritis patients

MK Demoruelle, KK Harrall, L Ho… - Arthritis & …, 2017 - Wiley Online Library
Objective Studies suggest that rheumatoid arthritis (RA)–related autoimmunity is initiated at
a mucosal site. However, the factors associated with the mucosal generation of this …